CLOCK polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human cerebral cortex with CLOCK polyclonal antibody (Cat# PAB29318) shows moderate nuclear positivity in neuronal cells.
Immunofluorescence
Immunofluorescent staining of human cell line U-251 MG with CLOCK polyclonal antibody (Cat# PAB29318) under 1-4 ug/mL working concentration shows positivity in nucleus but excluded from the nucleoli.
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant human CLOCK.
Immunogen
Recombinant protein corresponding to amino acids of human CLOCK.
Sequence
RQQEELRKIQEQLQMVHGQGLQMFLQQSNPGLNFGSVQLSSGNSSNIQQLAPINMQGQVVPTNQIQSGMNTGHIGTTQHMIQQQTLQSTSTQSQQNVLSGHSQQTSLPSQTQSTLTAPLYNTMVISQPAAGSMVQIPSSMPQNSTQS
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:20-1:50)
Immunofluorescence (1-4 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human cerebral cortex with CLOCK polyclonal antibody (Cat# PAB29318) shows moderate nuclear positivity in neuronal cells.Immunofluorescence
Immunofluorescent staining of human cell line U-251 MG with CLOCK polyclonal antibody (Cat# PAB29318) under 1-4 ug/mL working concentration shows positivity in nucleus but excluded from the nucleoli. -
Gene Info — CLOCK
Entrez GeneID
9575Protein Accession#
O15516Gene Name
CLOCK
Gene Alias
KAT13D, KIAA0334, bHLHe8
Gene Description
clock homolog (mouse)
Omim ID
601851Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that belongs to the basic helix-loop-helix (bHLH) family of transcription factors. Polymorphisms within the encoded protein have been associated with circadian rhythm sleep disorders. A similar protein in mice is a circadian regulator that acts as a transcription factor and forms a heterodimer with aryl hydrocarbon receptor nuclear translocator-like to activate transcription of mouse period 1. [provided by RefSeq
Other Designations
OTTHUMP00000128334|circadian locomoter output cycles kaput protein|clock
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Interactome
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Pathway
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Disease
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