Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human brain tissue with IGF1R (phospho Y1346) polyclonal antibody (Cat# PAB29290) without blocking peptide (A) or preincubated with blocking peptide (B) under 1:50-1:100 dilution.
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. [provided by RefSeq