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Last updated: 2017/5/28

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TGFBR2 (phospho S225/S250) polyclonal antibody

  • Catalog # : PAB29283
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic phosphopeptide of human TGFBR2.
  • Immunogen:
  • Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S225/S250 of human TGFBR2.
  • Host:
  • Rabbit
  • Theoretical MW (kDa):
  • 64
  • Reactivity:
  • Human
  • Specificity:
  • TGFBR2 (phospho S225/S250) polyclonal antibody detects endogenous levels of human TGFBR2 only when phosphorylated at serine 225/250.
  • Form:
  • Liquid
  • Purification:
  • Affinity Chromatography
  • Recommend Usage:
  • Immunohistochemistry (1:50~1:100)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (without Mg2+ and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human brain tissue with TGFBR2 (phospho S225/S250) polyclonal antibody (Cat# PAB29283) without blocking peptide (A) or preincubated with blocking peptide (B) under 1:50-1:100 dilution.
  • Application Image
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 7048
  • Gene Name:
  • TGFBR2
  • Gene Alias:
  • AAT3,FAA3,LDS1B,LDS2B,MFS2,RIIC,TAAD2,TGFR-2,TGFbeta-RII
  • Gene Description:
  • transforming growth factor, beta receptor II (70/80kDa)
  • Gene Summary:
  • This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq
  • Other Designations:
  • TGF-beta receptor type IIB,TGF-beta type II receptor,transforming growth factor beta receptor type IIC,transforming growth factor, beta receptor II,transforming growth factor, beta receptor II (70-80kD)
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