ITGB4 (phospho Y1510) polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of Lane 1: Na2VO3 treated HepG2 cells, Lane 2: antigen-specific peptide treated HepG2 cells with ITGB4 (phospho Y1510) polyclonal antibody (Cat# PAB29281) at 1:500-1:1000 dilution.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human breast cancer tissue with ITGB4 (phospho Y1510) polyclonal antibody (Cat# PAB29281) without blocking peptide (A) or preincubated with blocking peptide (B) under 1:50-1:100 dilution.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of human ITGB4.
Immunogen
Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding Y1510 of human ITGB4.
Host
Rabbit
Theoretical MW (kDa)
202
Reactivity
Human, Mouse, Rat
Specificity
ITGB4 (phospho Y1510) polyclonal antibody detects endogenous levels of human ITGB4 only when phosphorylated at tyrosine 1510.
Form
Liquid
Purification
Affinity Chromatography
Recommend Usage
Immunohistochemistry (1:50~1:100)
Western Blot (1:500~1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (without Mg2+ and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of Lane 1: Na2VO3 treated HepG2 cells, Lane 2: antigen-specific peptide treated HepG2 cells with ITGB4 (phospho Y1510) polyclonal antibody (Cat# PAB29281) at 1:500-1:1000 dilution.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human breast cancer tissue with ITGB4 (phospho Y1510) polyclonal antibody (Cat# PAB29281) without blocking peptide (A) or preincubated with blocking peptide (B) under 1:50-1:100 dilution. -
Gene Info — ITGB4
Entrez GeneID
3691Protein Accession#
P16144Gene Name
ITGB4
Gene Alias
CD104
Gene Description
integrin, beta 4
Gene Ontology
HyperlinkGene Summary
Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq
Other Designations
CD104 antigen|GP150|integrin beta 4|integrin beta-4 subunit
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Interactome
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Pathway
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Disease
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