Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human lung cancer tissue with HNRNPD (phospho S83) polyclonal antibody (Cat# PAB29280) without blocking peptide (A) or preincubated with blocking peptide (B) under 1:50-1:100 dilution.
Immunofluorescence staining of methanol-fixed HeLa cells with HNRNPD (phospho S83) polyclonal antibody (Cat# PAB29280) without blocking peptide (A) or preincubated with blocking peptide (B) at 1:100-1:200 dilution.
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants. [provided by RefSeq
ARE-binding protein AUFI, type A,AU-rich element RNA-binding protein 1,heterogeneous nuclear ribonucleoprotein D,heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA-binding protein 1, 37kD)