GAB2 (phospho S623) polyclonal antibody
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More Files
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Western Blot (Cell lysate)
Western blot analysis of Lane 1: antigen-specific peptide treated 293 cells, Lane 2: 293 cells, Lane 3: HeLa cells, Lane 4: HepG2 cells with GAB2 (phospho S623) polyclonal antibody (Cat # PAB29245) at 1:500-1000 dilution.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human breast carcinoma tissue by GAB2 (phospho S623) polyclonal antibody (Cat # PAB29245) without blocking peptide (A) or preincubated with blocking peptide (B) under 1:50-1:100 dilution.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of human GAB2.
Immunogen
Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S623 of human GAB2.
Host
Rabbit
Theoretical MW (kDa)
80
Reactivity
Human, Mouse
Specificity
This antibody detects endogenous levels of GAB2 only when phosphorylated at serine 623.
Form
Liquid
Purification
Affinity purification
Recommend Usage
Immunohistochemistry (1:50-1:100)
Western Blot (1:500-1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (without Mg2+ and Ca2+), (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Avoid repeated freezing and thawing. -
Applications
Western Blot (Cell lysate)
Western blot analysis of Lane 1: antigen-specific peptide treated 293 cells, Lane 2: 293 cells, Lane 3: HeLa cells, Lane 4: HepG2 cells with GAB2 (phospho S623) polyclonal antibody (Cat # PAB29245) at 1:500-1000 dilution.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human breast carcinoma tissue by GAB2 (phospho S623) polyclonal antibody (Cat # PAB29245) without blocking peptide (A) or preincubated with blocking peptide (B) under 1:50-1:100 dilution. -
Gene Info — GAB2
Entrez GeneID
9846Protein Accession#
Q9UQC2Gene Name
GAB2
Gene Alias
KIAA0571
Gene Description
GRB2-associated binding protein 2
Omim ID
606203Gene Ontology
HyperlinkGene Summary
This gene is a member of the GRB2-associated binding protein (GAB) gene family and is similar to the GAB1 gene. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq
Other Designations
Grb2-associated binder 2
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Interactome
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Pathway
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Disease
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