Western blot analysis of Lane 1: antigen-specific peptide treated 293 cells, Lane 2: 293 cells, Lane 3: HeLa cells, Lane 4: HepG2 cells with GAB2 (phospho S623) polyclonal antibody (Cat # PAB29245) at 1:500-1000 dilution.
Immunohistochemical staining of human breast carcinoma tissue by GAB2 (phospho S623) polyclonal antibody (Cat # PAB29245) without blocking peptide (A) or preincubated with blocking peptide (B) under 1:50-1:100 dilution.
This gene is a member of the GRB2-associated binding protein (GAB) gene family and is similar to the GAB1 gene. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq