Immunohistochemical staining of human colon carcinoma tissue by CAD (phospho T456) polyclonal antibody (Cat # PAB29236) without blocking peptide (A) or preincubated with blocking peptide (B) under 1:50-1:100 dilution.
The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. [provided by RefSeq
CAD trifunctional protein,carbamoylphosphate synthetase 2/aspartate transcarbamylase/dihydroorotase,multifunctional protein CAD