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CAD (phospho T456) polyclonal antibody

  • Catalog # : PAB29236
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic phosphopeptide of human CAD.
  • Immunogen:
  • Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding T456 of human CAD.
  • Host:
  • Rabbit
  • Theoretical MW (kDa):
  • 242
  • Reactivity:
  • Human, Mouse
  • Specificity:
  • This antibody detects endogenous levels of CAD only when phosphorylated at threonine 456.
  • Form:
  • Liquid
  • Purification:
  • Affinity purification
  • Recommend Usage:
  • Immunohistochemistry (1:50-1:100)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.4 (without Mg2+ and Ca2+), (50% glycerol, 0.02% sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Avoid repeated freezing and thawing.
  • Applications
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical staining of human colon carcinoma tissue by CAD (phospho T456) polyclonal antibody (Cat # PAB29236) without blocking peptide (A) or preincubated with blocking peptide (B) under 1:50-1:100 dilution.
  • Application Image
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
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  • Gene Information
  • Entrez GeneID:
  • 790
  • Gene Name:
  • CAD
  • Gene Alias:
  • -
  • Gene Description:
  • carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
  • Gene Summary:
  • The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. [provided by RefSeq
  • Other Designations:
  • CAD trifunctional protein,carbamoylphosphate synthetase 2/aspartate transcarbamylase/dihydroorotase,multifunctional protein CAD
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