CAD (phospho T456) polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human colon carcinoma tissue by CAD (phospho T456) polyclonal antibody (Cat # PAB29236) without blocking peptide (A) or preincubated with blocking peptide (B) under 1:50-1:100 dilution.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of human CAD.
Immunogen
Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding T456 of human CAD.
Host
Rabbit
Theoretical MW (kDa)
242
Reactivity
Human, Mouse
Specificity
This antibody detects endogenous levels of CAD only when phosphorylated at threonine 456.
Form
Liquid
Purification
Affinity purification
Recommend Usage
Immunohistochemistry (1:50-1:100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (without Mg2+ and Ca2+), (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Avoid repeated freezing and thawing. -
Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human colon carcinoma tissue by CAD (phospho T456) polyclonal antibody (Cat # PAB29236) without blocking peptide (A) or preincubated with blocking peptide (B) under 1:50-1:100 dilution. -
Gene Info — CAD
Entrez GeneID
790Protein Accession#
P27708Gene Name
CAD
Gene Alias
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Gene Description
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Omim ID
114010Gene Ontology
HyperlinkGene Summary
The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. [provided by RefSeq
Other Designations
CAD trifunctional protein|carbamoylphosphate synthetase 2/aspartate transcarbamylase/dihydroorotase|multifunctional protein CAD
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Interactome
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Pathway
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Disease
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