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WWOX (phospho Y33) polyclonal antibody

  • Catalog # : PAB29231
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic phosphopeptide of human WWOX.
  • Immunogen:
  • Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding Y33 of human WWOX.
  • Host:
  • Rabbit
  • Theoretical MW (kDa):
  • 55
  • Reactivity:
  • Human, Mouse
  • Specificity:
  • This antibody detects endogenous levels of WWOX only when phosphorylated at tyrosine 33.
  • Form:
  • Liquid
  • Purification:
  • Affinity purification
  • Recommend Usage:
  • Immunohistochemistry (1:50-1:100)
    Western Blot (1:500-1000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.4 (without Mg2+ and Ca2+), (50% glycerol, 0.02% sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Avoid repeated freezing and thawing.
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of Lane 1: PMA treated HepG2 cells, Lane 2: antigen-specific peptide treated HepG2 cells with WWOX (phospho Y33) polyclonal antibody (Cat # PAB29231) at 1:500-1000 dilution.
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical staining of human colon carcinoma tissue by WWOX (phospho Y33) polyclonal antibody (Cat # PAB29231) without blocking peptide (A) or preincubated with blocking peptide (B) under 1:50-1:100 dilution.
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Gene Information
  • Gene Name:
  • WWOX
  • Gene Alias:
  • D16S432E,FOR,FRA16D,HHCMA56,PRO0128,SDR41C1,WOX1
  • Gene Description:
  • WW domain containing oxidoreductase
  • Gene Summary:
  • WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms. [provided by RefSeq
  • Other Designations:
  • WW domain-containing oxidoreductase,WW domain-containing protein WWOX,fragile 16D oxido reductase,fragile site FRA16D oxidoreductase,putative oxidoreductase,short chain dehydrogenase/reductase family 41C, member 1
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