WWOX (phospho Y33) polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of Lane 1: PMA treated HepG2 cells, Lane 2: antigen-specific peptide treated HepG2 cells with WWOX (phospho Y33) polyclonal antibody (Cat # PAB29231) at 1:500-1000 dilution.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human colon carcinoma tissue by WWOX (phospho Y33) polyclonal antibody (Cat # PAB29231) without blocking peptide (A) or preincubated with blocking peptide (B) under 1:50-1:100 dilution.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of human WWOX.
Immunogen
Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding Y33 of human WWOX.
Host
Rabbit
Theoretical MW (kDa)
55
Reactivity
Human, Mouse
Specificity
This antibody detects endogenous levels of WWOX only when phosphorylated at tyrosine 33.
Form
Liquid
Purification
Affinity purification
Recommend Usage
Immunohistochemistry (1:50-1:100)
Western Blot (1:500-1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (without Mg2+ and Ca2+), (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Avoid repeated freezing and thawing. -
Applications
Western Blot (Cell lysate)
Western blot analysis of Lane 1: PMA treated HepG2 cells, Lane 2: antigen-specific peptide treated HepG2 cells with WWOX (phospho Y33) polyclonal antibody (Cat # PAB29231) at 1:500-1000 dilution.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human colon carcinoma tissue by WWOX (phospho Y33) polyclonal antibody (Cat # PAB29231) without blocking peptide (A) or preincubated with blocking peptide (B) under 1:50-1:100 dilution. -
Gene Info — WWOX
Entrez GeneID
51741Protein Accession#
Q96KM3Gene Name
WWOX
Gene Alias
D16S432E, FOR, FRA16D, HHCMA56, PRO0128, SDR41C1, WOX1
Gene Description
WW domain containing oxidoreductase
Gene Ontology
HyperlinkGene Summary
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms. [provided by RefSeq
Other Designations
WW domain-containing oxidoreductase|WW domain-containing protein WWOX|fragile 16D oxido reductase|fragile site FRA16D oxidoreductase|putative oxidoreductase|short chain dehydrogenase/reductase family 41C, member 1
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Interactome
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