Immunohistochemical staining of human brain tissue by STK39 (phospho S325) polyclonal antibody (Cat # PAB29219) without blocking peptide (A) or preincubated with blocking peptide (B) under 1:50-1:100 dilution.
This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. [provided by RefSeq
Ste20-like protein kinase,proline-alanine-rich STE20-related kinase,small intestine SPAK-like kinase