Immunohistochemical staining of human breast carcinoma tissue by PAK2 (phospho S197) polyclonal antibody (Cat # PAB29216) without blocking peptide (A) or preincubated with blocking peptide (B) under 1:50-1:100 dilution.
The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq