MAP2K7 (phospho S271) polyclonal antibody
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More Files
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Western Blot (Cell lysate)
Western blot analysis of Lane 1: insulin treated 3T3 cells Lane 2: antigen-specific peptide treated 3T3 cells with MAP2K7 (phospho S271) polyclonal antibody (Cat # PAB29211) at 1:500-1000 dilution.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human brain tissue by MAP2K7 (phospho S271) polyclonal antibody (Cat # PAB29211) without blocking peptide (A) or preincubated with blocking peptide (B) under 1:50-1:100 dilution.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of human MAP2K7.
Immunogen
Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S271 of human MAP2K7.
Host
Rabbit
Theoretical MW (kDa)
60
Reactivity
Human, Mouse, Rat
Specificity
This antibody detects endogenous levels of MAP2K7 only when phosphorylated at serine 271.
Form
Liquid
Purification
Affinity purification
Recommend Usage
Immunohistochemistry (1:50-1:100)
Western Blot (1:500-1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (without Mg2+ and Ca2+), (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Avoid repeated freezing and thawing. -
Applications
Western Blot (Cell lysate)
Western blot analysis of Lane 1: insulin treated 3T3 cells Lane 2: antigen-specific peptide treated 3T3 cells with MAP2K7 (phospho S271) polyclonal antibody (Cat # PAB29211) at 1:500-1000 dilution.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human brain tissue by MAP2K7 (phospho S271) polyclonal antibody (Cat # PAB29211) without blocking peptide (A) or preincubated with blocking peptide (B) under 1:50-1:100 dilution. -
Gene Info — MAP2K7
Entrez GeneID
5609Protein Accession#
O14733Gene Name
MAP2K7
Gene Alias
Jnkk2, MAPKK7, MKK7, PRKMK7
Gene Description
mitogen-activated protein kinase kinase 7
Omim ID
603014Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined. [provided by RefSeq
Other Designations
JNK kinase 2|JNK-activating kinase 2|MAP kinase kinase 7|OTTHUMP00000174397|c-Jun N-terminal kinase kinase 2|dual specificity mitogen-activated protein kinase kinase 7
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Interactome
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Pathway
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