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IGL@ polyclonal antibody

  • Catalog # : PAB29189
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  • Specification
  • Product Description:
  • Chicken polyclonal antibody raised against native Human IGL@.
  • Immunogen:
  • Native purified human immunoglobulin lambda light chain.
  • Host:
  • Chicken
  • Reactivity:
  • Human
  • Specificity:
  • This antibody reacts with all human immunoglobulin classes possessing lambda chains and free lambda light chains, but not kappa chains.
  • Form:
  • Liquid
  • Purification:
  • Antigen affinity purification
  • Isotype:
  • IgY
  • Recommend Usage:
  • ELISA (1:200-1:500)
    Western Blot (1:1000-1:5000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.2 (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot
  • ELISA
  • Application Image
  • Western Blot
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 3535
  • Gene Name:
  • IGL@
  • Gene Alias:
  • IGL,MGC88804
  • Gene Description:
  • immunoglobulin lambda locus
  • Gene Summary:
  • Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the complement system. Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. There are two classes of light chains, kappa and lambda. This region represents the germline organization of the lambda light chain locus. The locus includes V (variable), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single V segment with a J segment; the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. Several V segments and three C segments are known to be incapable of encoding a protein and are considered pseudogenes. The locus also includes several non-immunoglobulin genes, many of which are pseudogenes or are predicted by automated computational analysis or homology to other species. [provided by RefSeq
  • Other Designations:
  • immunoglobulin lambda gene cluster
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