TH polyclonal antibody
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Specification
Product Description
Chicken polyclonal antibody raised against recombinant Human TH.
Immunogen
Two different KLH-conjugated synthetic peptides corresponding to different regions of the TH gene product. These peptide sequences were shared between the mouse (P24529) and human (P07101) gene products.
Host
Chicken
Reactivity
Human, Mouse
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgY
Quality Control Testing
Immunohistochemistry
TH polyclonal antibody (Cat # PAB29094) was analyzed by immunohistochemical staining (at a concentration of 3 ug/mL).
Immunohistological staining in the mouse subcutania nigra section.Recommend Usage
Immunocytochemistry(1:1000-1:2000)
Immunohistochemistry(1:1000-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (0.02% sodium azide)
Storage Instruction
Store at 4°C and avoid from light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry
Immunocytochemistry
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Gene Info — TH
Entrez GeneID
7054Protein Accession#
P07101Gene Name
TH
Gene Alias
TYH
Gene Description
tyrosine hydroxylase
Omim ID
191290Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000011225|OTTHUMP00000011226|tyrosine 3-monooxygenase
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Gene Info — Th
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Interactome
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Pathway
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Disease
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Publication Reference
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Effects of estradiol on dopaminergic synapse formation in the mouse olfactory bulb.
Emi Kiyokage, Satoshi Ichikawa, Sawa Horie, Shuichi Hayashi, Kazunori Toida.
The Journal of Comparative Neurology 2023 Mar; 531(4):528.
Application:IF, Mouse, Mouse coronal.
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Neurons generated from carcinoma stem cells support cancer progression.
Lu R, Fan C, Shangguan W, Liu Y, Li Y, Shang Y, Yin D, Zhang S, Huang Q, Li X, MengW, Xu H, Zhou Z, Hu J, Li W, Liu L, Mo X.
Signal Transduction and Targeted Therapy 2017 Jan; 2:e16036.
Application:IF, Human, Human gastric and colorectal cancer stem cells.
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Effects of estradiol on dopaminergic synapse formation in the mouse olfactory bulb.
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