MBP polyclonal antibody
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More Files
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Immunocytological staining of MBP polyclonal antibody (Cat # PAB29078) (at a concentration of 3 ug/mL).
MBP-positive myelin (red) in cortical white matter from a GFP-expressing transgenic adult mouse.
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Specification
Product Description
Chicken polyclonal antibody raised against recombinant Human MBP.
Immunogen
A KLH-conjugated synthetic peptide shared between the human (NP_002376, NCBI) and mouse (NP_034907, NCBI) sequences.
Host
Chicken
Reactivity
Human, Mouse
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgY
Quality Control Testing
Immunocytochemistry
Immunocytological staining of MBP polyclonal antibody (Cat # PAB29078) (at a concentration of 3 ug/mL).
MBP-positive myelin (red) in cortical white matter from a GFP-expressing transgenic adult mouse.Recommend Usage
Immunocytochemistry(1:1000-1:2000)
Immunohistochemistry(1:1000-1:2000)
Western Blot(1:2000-1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (0.02% sodium azide)
Storage Instruction
Store at 4°C and avoid from light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry
Immunocytochemistry
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Gene Info — MBP
Entrez GeneID
4155Protein Accession#
NP_002376Gene Name
MBP
Gene Alias
MGC99675
Gene Description
myelin basic protein
Omim ID
159430Gene Ontology
HyperlinkGene Summary
The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. [provided by RefSeq
Other Designations
Golli-mbp|OTTHUMP00000174383|OTTHUMP00000174384|OTTHUMP00000174385|OTTHUMP00000174386
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Gene Info — Mbp
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Interactome
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Disease
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