GAD1 polyclonal antibody
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The antibody was analyzed by immunocytological staining (at a dilution of 1:1000) using fluorescein-labeled goat anti-chicken IgY (1:500 dilution) as the secondary reagent.
A tissue section through an adult mouse brain showing GAD1 (red staining) in basket cells of the hippocampal formation. Green staining is autofluorescence from GFP expressed in this transgenic mouse.
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Specification
Product Description
Chicken polyclonal antibody raised against recombinant Human GAD1.
Immunogen
A KLH-conjugated synthetic peptide corresponding to a region near the C-terminus of GAD1 gene product, and was 100% conserved between the human (Q99259, NCBI), mouse (P48318, NCBI) and rat (NP_058703, NCBI) gene products.
Host
Chicken
Reactivity
Human, Mouse, Rat
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgY
Quality Control Testing
Immunocytochemistry
The antibody was analyzed by immunocytological staining (at a dilution of 1:1000) using fluorescein-labeled goat anti-chicken IgY (1:500 dilution) as the secondary reagent.
A tissue section through an adult mouse brain showing GAD1 (red staining) in basket cells of the hippocampal formation. Green staining is autofluorescence from GFP expressed in this transgenic mouse.Recommend Usage
Immunocytochemistry(1:1000-1:2000)
Immunohistochemistry(1:1000-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (0.02% sodium azide)
Storage Instruction
Store at 4°C and avoid from light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry
Immunocytochemistry
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Gene Info — GAD1
Entrez GeneID
2571Protein Accession#
Q99259Gene Name
GAD1
Gene Alias
FLJ45882, GAD, SCP
Gene Description
glutamate decarboxylase 1 (brain, 67kDa)
Gene Ontology
HyperlinkGene Summary
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. [provided by RefSeq
Other Designations
OTTHUMP00000041055|glutamate decarboxylase 1|glutamate decarboxylase 1 (brain, 67kD)
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Gene Info — Gad1
Entrez GeneID
14415Protein Accession#
Q99259Gene Name
Gad1
Gene Alias
EP10, GAD25, GAD44, GAD67, Gad-1
Gene Description
glutamic acid decarboxylase 1
Gene Ontology
HyperlinkGene Summary
67 KD ISOFORM (GAD-67) (67 KD GLUTAMIC ACID DECARBOXYLASE)
Other Designations
GLUTAMATE DECARBOXYLASE, 67 KD ISOFORM (GAD-67) (67 KD GLUTAMIC ACID DECARBOXYLASE)
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Gene Info — Gad1
Entrez GeneID
24379Protein Accession#
Q99259Gene Name
Gad1
Gene Alias
Gad67
Gene Description
glutamate decarboxylase 1
Gene Ontology
HyperlinkOther Designations
Glutamate decarboxylase 1 (brain)|glutamate decarboxylase 1 variant GAD67NT|glutamate decarboxylase 67 kDa isoform|glutamic acid decarboxylase 1
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Interactome
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Pathway
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Disease
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