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GAD1 polyclonal antibody

  • Catalog # : PAB29073
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  • Specification
  • Product Description:
  • Chicken polyclonal antibody raised against recombinant Human GAD1.
  • Immunogen:
  • A KLH-conjugated synthetic peptide corresponding to a region near the C-terminus of GAD1 gene product, and was 100% conserved between the human (Q99259, NCBI), mouse (P48318, NCBI) and rat (NP_058703, NCBI) gene products.
  • Host:
  • Chicken
  • Reactivity:
  • Human, Mouse, Rat
  • Form:
  • Liquid
  • Purification:
  • Antigen affinity purification
  • Isotype:
  • IgY
  • Quality Control Testing:
  • Immunocytochemistry

    QC Testing of PAB29073
    The antibody was analyzed by immunocytological staining (at a dilution of 1:1000) using fluorescein-labeled goat anti-chicken IgY (1:500 dilution) as the secondary reagent.
    A tissue section through an adult mouse brain showing GAD1 (red staining) in basket cells of the hippocampal formation. Green staining is autofluorescence from GFP expressed in this transgenic mouse.
  • Recommend Usage:
  • Immunocytochemistry(1:1000-1:2000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.2 (0.02% sodium azide)
  • Storage Instruction:
  • Store at 4°C and avoid from light.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Immunohistochemistry
  • Immunocytochemistry
  • Application Image
  • Immunohistochemistry
  • Immunocytochemistry
  • Gene Information
  • Entrez GeneID:
  • 2571
  • Gene Name:
  • GAD1
  • Gene Alias:
  • FLJ45882,GAD,SCP
  • Gene Description:
  • glutamate decarboxylase 1 (brain, 67kDa)
  • Gene Summary:
  • This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000041055,glutamate decarboxylase 1,glutamate decarboxylase 1 (brain, 67kD)
  • Gene Information
  • Gene Name:
  • Gad1
  • Gene Alias:
  • EP10,GAD25,GAD44,GAD67,Gad-1
  • Gene Description:
  • glutamic acid decarboxylase 1
  • Other Designations:
  • Gene Information
  • Gene Name:
  • Gad1
  • Gene Alias:
  • Gad67
  • Gene Description:
  • glutamate decarboxylase 1
  • Other Designations:
  • Glutamate decarboxylase 1 (brain),glutamate decarboxylase 1 variant GAD67NT,glutamate decarboxylase 67 kDa isoform,glutamic acid decarboxylase 1
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