Chicken polyclonal antibody raised against recombinant Human DCX.
Two different KLH-conjugated synthetic peptides corresponding to different regions of DCX gene product, shared between the human (CAA06617.1, NCBI) and mouse (AAT58219.1, NCBI) sequences.
Antigen affinity purification
Quality Control Testing:
DCX polyclonal antibody (Cat # PAB29068) was validated by immunocytological staining (at a concentration of 2 ug/mL). DCX-staining of cochlear neurons in the cochlear ganglion of an adult mouse brain (green staining). Red staining is neurofilament immunoreactivity with a rabbit antibody.
Immunocytochemistry(1:1000-1:2000) Immunohistochemistry(1:1000-1:2000) The optimal working dilution should be determined by the end user.
In PBS, pH 7.2 (0.02% sodium azide)
Store at 4°C and avoid from light. Aliquot to avoid repeated freezing and thawing.
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The protein encoded by this gene is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules. The encoded protein contains two doublecortin domains, which bind microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene are a cause of X-linked lissencephaly. Multiple transcript variants encoding at least three different isoforms have been found for this gene. [provided by RefSeq