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DCX polyclonal antibody

  • Catalog # : PAB29068
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  • Specification
  • Product Description:
  • Chicken polyclonal antibody raised against recombinant Human DCX.
  • Immunogen:
  • Two different KLH-conjugated synthetic peptides corresponding to different regions of DCX gene product, shared between the human (CAA06617.1, NCBI) and mouse (AAT58219.1, NCBI) sequences.
  • Host:
  • Chicken
  • Reactivity:
  • Human, Mouse
  • Form:
  • Liquid
  • Purification:
  • Antigen affinity purification
  • Isotype:
  • IgY
  • Quality Control Testing:
  • Immunocytochemistry

    QC Testing of PAB29068
    DCX polyclonal antibody (Cat # PAB29068) was validated by immunocytological staining (at a concentration of 2 ug/mL).
    DCX-staining of cochlear neurons in the cochlear ganglion of an adult mouse brain (green staining). Red staining is neurofilament immunoreactivity with a rabbit antibody.
  • Recommend Usage:
  • Immunocytochemistry(1:1000-1:2000)
    Immunohistochemistry(1:1000-1:2000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.2 (0.02% sodium azide)
  • Storage Instruction:
  • Store at 4°C and avoid from light.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Immunohistochemistry
  • Immunocytochemistry
  • Application Image
  • Immunohistochemistry
  • Immunocytochemistry
  • Gene Information
  • Entrez GeneID:
  • 1641
  • Gene Name:
  • DCX
  • Gene Alias:
  • DBCN,DC,LISX,SCLH,XLIS
  • Gene Description:
  • doublecortin
  • Gene Summary:
  • In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The protein encoded by this gene is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules. The encoded protein contains two doublecortin domains, which bind microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene are a cause of X-linked lissencephaly. Multiple transcript variants encoding at least three different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000062892,doublecortex,doublin,lissencephalin-X
  • Gene Information
  • Gene Name:
  • Dcx
  • Gene Alias:
  • Dbct
  • Gene Description:
  • doublecortin
  • Other Designations:
  • OTTMUSP00000020397,doublecortex,lissencephaly, X-linked (doublecortin)
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