Chicken polyclonal antibody raised against recombinant APP.
A KLH-conjugated synthetic peptide corresponding to residues 1-17 of the amyloid-beta peptide.
Antigen affinity purification
Quality Control Testing:
APP polyclonal antibody (Cat # PAB29064) was analyzed by immunohistochemical staining at a concentration of 3 ug/mL using fluorescein-labeled goat anti-chicken IgY at 1:500 dilution or HRP-labeled goat anti-chicken IgY at 1:2000 dilution as the secondary reagent.
Immunocytochemistry Immunohistochemistry The optimal working dilution should be determined by the end user.
In PBS, pH 7.2 (0.02% sodium azide)
Store at 4°C and avoid from light. Aliquot to avoid repeated freezing and thawing.
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq