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Last updated: 2018/6/17

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APP fibrils polyclonal antibody (RPE )

  • Catalog # : PAB28926
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody against amyloid fibrils and fibrillar oligomers.
  • Immunogen:
  • Fibrils prepared from human Abeta42 peptide.
  • Host:
  • Rabbit
  • Reactivity:
  • Human, Mouse, Rat
  • Specificity:
  • PAB28926 recognizes generic epitopes common to many amyloid fibrils and fibrillar oligomers, but not prefibrilllar oligomers or natively folded proteins. 1:1000 dilution of PAB28926 was sufficient for detection of amyloid oligomers in 10ug of mouse brain lysates by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.
  • Form:
  • Liquid
  • Conjugation:
  • RPE
  • Purification:
  • Protein A affinity purification
  • Recommend Usage:
  • Dot blot (1:1000)
    Western Blot
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • PBS pH7.4, 50% glycerol and 0.09% sodium azide
  • Storage Instruction:
  • Store at 4°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • Application Data with Unconjugated Antibody
  • Western Blot

    Western blot analysis of Abeta42 fibrils (Lane 1, Lane 3) and prefibrillar oligomers (Lane 2, Lane 4) with APP fibrils polyclonal antibody(Cat # PAB28910; Lane 1, Lane 2) and APP oligomers polyclonal antibody (Cat # PAB28928; Lane 3, Lane 4).

    Dot Blot

    Dot blot analysis of Abeta42 and polyQ36 prefibrillar oligomers and fibrils with APP oligomers polyclonal antibody (Cat # PAB28928) and APP fibrils polyclonal antibody (Cat # PAB28910).

  • Applications
  • Western Blot
  • Immunohistochemistry
  • Immunocytochemistry
  • Immunoprecipitation
  • Dot Blot
  • Application Image
  • Western Blot
  • Immunohistochemistry
  • Immunocytochemistry
  • Immunoprecipitation
  • Dot Blot
  • Gene Information
  • Entrez GeneID:
  • 351
  • Gene Name:
  • APP
  • Gene Alias:
  • Gene Description:
  • amyloid beta (A4) precursor protein
  • Gene Summary:
  • This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • A4 amyloid protein,amyloid beta A4 protein,amyloid-beta protein,beta-amyloid peptide,cerebral vascular amyloid peptide,peptidase nexin-II,protease nexin-II
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  • Interactome
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