LARS polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of LARS.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human LARS.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Ammonium sulfate precipitation
Recommend Usage
Western Blot (1:1000)
Immunohistochemsitry (1:10-50)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of LARS polyclonal antibody (Cat # PAB2886) in 293 cell line lysates (35 ug/lane). LARS (arrow) was detected using the purified polyclonal antibody.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human prostate carcinomareacted with LARS polyclonal antibody (Cat # PAB2886), which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. -
Gene Info — LARS
Entrez GeneID
51520Protein Accession#
NP_064502;Q9P2J5Gene Name
LARS
Gene Alias
FLJ10595, FLJ21788, HSPC192, KIAA1352, LARS1, LEURS, LEUS, LRS, PIG44, RNTLS, hr025Cl
Gene Description
leucyl-tRNA synthetase
Omim ID
151350Gene Ontology
HyperlinkGene Summary
This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. Alternatively spliced transcript variants of this gene have been found; however, their full-length nature is not known. [provided by RefSeq
Other Designations
cytoplasmic leucyl-tRNA synthetase|cytosolic leucyl-tRNA synthetase|leucine tRNA ligase 1, cytoplasmic|leucine translase|leucine-tRNA ligase|proliferation-inducing gene 44
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Interactome
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Pathway
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Disease
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Publication Reference
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A single residue in leucyl-tRNA synthetase affecting amino acid specificity and tRNA aminoacylation.
Lue SW, Kelley SO.
Biochemistry 2007 Mar; 46(15):4466.
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The C-terminal appended domain of human cytosolic leucyl-tRNA synthetase is indispensable in its interaction with arginyl-tRNA synthetase in the multi-tRNA synthetase complex.
Ling C, Yao YN, Zheng YG, Wei H, Wang L, Wu XF, Wang ED.
The Journal of Biological Chemistry 2005 Oct; 280(41):34755.
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Assignment of a human genetic locus to chromosome 5 which corrects the heat sensitive lesion associated with reduced leucyl-tRNA synthetase activity in ts025Cl Chinese hamster cells.
R E Giles, N Shimizu, F H Ruddle.
Somatic Cell Genetics 1980 Sep; 6(5):667.
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A single residue in leucyl-tRNA synthetase affecting amino acid specificity and tRNA aminoacylation.
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