APOA5 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of APOA5.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human APOA5.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Ammonium sulfate precipitation
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of APOA5 polyclonal antibody (Cat # PAB2885) in HL-60 cell line lysates (35 ug/lane).APOA5 (arrow) was detected using the purified polyclonal antibody.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocarcinomareacted with APOA5 polyclonal antibody (Cat # PAB2885), which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. -
Gene Info — APOA5
Entrez GeneID
116519Protein Accession#
NP_443200.2;Q6Q788Gene Name
APOA5
Gene Alias
APOA-V, APOAV, MGC126836, MGC126838, RAP3
Gene Description
apolipoprotein A-V
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is an apolipoprotein and an important determinant of plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of high density lipoprotein and is highly similar to a rat protein that is upregulated in response to liver injury. This gene uses alternate polyadenylation sites and is located proximal to the apolipoprotein gene cluster on chromosome 11q23. [provided by RefSeq
Other Designations
apolipoprotein A-V precursor variant 1|apolipoprotein A-V precursor variant 2|apolipoprotein A5|apolipoprotein AV|regeneration-associated protein 3
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Interactome
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Pathway
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Disease
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Publication Reference
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Effects of six APOA5 variants, identified in patients with severe hypertriglyceridemia, on in vitro lipoprotein lipase activity and receptor binding.
Dorfmeister B, Zeng WW, Dichlberger A, Nilsson SK, Schaap FG, Hubacek JA, Merkel M, Cooper JA, Lookene A, Putt W, Whittall R, Lee PJ, Lins L, Delsaux N, Nierman M, Kuivenhoven JA, Kastelein JJ, Vrablik M, Olivecrona G, Schneider WJ, Heeren J, Humphries SE, Talmud PJ.
Arteriosclerosis, Thrombosis, and Vascular Biology 2008 Oct; 28(10):1866.
Application:WB-Re, Human, Human, serum, Recombinant protein.
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APOA5 Ala315>Val, identified in patients with severe hypertriglyceridemia, is a common mutation with no major effects on plasma lipid levels.
Hubacek JA, Wang WW, Skodova Z, Adamkova V, Vrablik M, Horinek A, Stulc T, Ceska R, Talmud PJ.
Clin Chem Lab Med 2008 Jan; 46(6):773.
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CHRM2 gene predisposes to alcohol dependence, drug dependence and affective disorders: results from an extended case-control structured association study.
Luo X, Kranzler HR, Zuo L, Wang S, Blumberg HP, Gelernter J.
Human Molecular Genetics 2005 Jul; 14(16):2421.
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Effects of six APOA5 variants, identified in patients with severe hypertriglyceridemia, on in vitro lipoprotein lipase activity and receptor binding.
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