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MED12 polyclonal antibody

  • Catalog # : PAB28711
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against recombinant MED12.
  • Immunogen:
  • Recombinant protein corresponding to amino acids of human MED12.
  • Sequence:
  • LPTTMTGVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTS
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Purification:
  • Antigen affinity purification
  • Isotype:
  • IgG
  • Recommend Usage:
  • Immunohistochemistry (1:20-1:50)
    Immunofluorescence (1-4 ug/ml)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Immunohistochemistry
  • Immunohistochemistry
  • Immunohistochemical staining of human bone marrow with MED12 polyclonal antibody (Cat # PAB28711) show strong nuclear positivity in bone marrow poietic cells.
  • Immunofluorescence
  • Immunofluorescence
  • Immunofluorescent staining of human cell line U-2 OS with MED12 polyclonal antibody (Cat # PAB28711) at 1-4 ug/mL dilution shows positivity in nuclei but not nucleoli.
  • Application Image
  • Gene Information
  • Entrez GeneID:
  • 9968
  • Gene Name:
  • MED12
  • Gene Alias:
  • CAGH45,FGS1,HOPA,KIAA0192,OKS,OPA1,TNRC11,TRAP230
  • Gene Description:
  • mediator complex subunit 12
  • Gene Summary:
  • The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq
  • Other Designations:
  • FG syndrome 1,OPA-containing protein,OTTHUMP00000023491,mediator of RNA polymerase II transcription, subunit 12 homolog,thyroid hormone receptor-associated protein, 230 kDa subunit,trinucleotide repeat containing 11 (THR-associated protein, 230 kDa subuni
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