Western blot analysis of Lane 1: Negative control (vector only transfected HEK293T lysate) Lane 2: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells) with BGN polyclonal antibody (Cat # PAB28699).
Immunohistochemical staining of human placenta with BGN polyclonal antibody (Cat # PAB28699) strong cytoplasmic positivity in trophoblastic cells.
The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to two other small proteoglycans, decorin and fibromodulin. The encoded protein and decorin are thought to be the result of a gene duplication. Decorin contains one attached glycosaminoglycan chain, while this protein probably contains two chains. For this reason, this protein is called biglycan. This protein is thought to function in connective tissue metabolism by binding to collagen fibrils and transfering growth factor-beta. It may promote neuronal survival. This gene is a candidate gene for the Happle syndrome. [provided by RefSeq
OTTHUMP00000025928,biglycan proteoglycan,bone/cartilage proteoglycan-I,dermatan sulphate proteoglycan I,small leucine-rich protein 1A