Western blot anyalysis of Lane 1: Negative control (vector only transfected HEK293T lysate), Lane 2: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY418207) with FGF13 polyclonal antibody (Cat # PAB28687) at 1:100-1:250 dilution.
Immunohistochemical staining of human hippocampus with FGF13 polyclonal antibody (Cat # PAB28687) shows strong nucleolar and cytoplasmic positivity in neuronal cells at 1:50-1:200 dilution.
Immunofluorescent staining of human cell line A-431 with FGF13 polyclonal antibody (Cat # PAB28687) at 1-4 ug/mL shows positivity in cytoplasm.
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene is located in a region on chromosome X, which is associated with Borjeson-Forssman-Lehmann syndrome (BFLS), making it a possible candidate gene for familial cases of the BFLS, and for other syndromal and nonspecific forms of X-linked mental retardation mapping to this region. Alternative splicing of this gene at the 5' end results in several transcript variants encoding different isoforms with different N-termini. [provided by RefSeq