ABCC4 polyclonal antibody
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More Files
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Immunohistochemistry
Immunohistochemical staining of human prostate with ABCC4 polyclonal antibody (Cat # PAB28670) shows cytoplasmic and membranous positivity in glandular cells at 1:200-1:500 dilution.
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant ABCC4.
Immunogen
Recombinant protein corresponding to amino acids of human ABCC4.
Sequence
NFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMVQQLGKAEAAALTETAKQVYFKRNYPHIGHTDHMVTNTSNGQPST
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:200-1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry
Immunohistochemical staining of human prostate with ABCC4 polyclonal antibody (Cat # PAB28670) shows cytoplasmic and membranous positivity in glandular cells at 1:200-1:500 dilution. -
Gene Info — ABCC4
Entrez GeneID
10257Gene Name
ABCC4
Gene Alias
EST170205, MOAT-B, MOATB, MRP4
Gene Description
ATP-binding cassette, sub-family C (CFTR/MRP), member 4
Omim ID
605250Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in cellular detoxification as a pump for its substrate, organic anions. Alternative splicing results in multiple splice variants encoding different isoforms. [provided by RefSeq
Other Designations
ATP-binding cassette, sub-family C, member 4|OTTHUMP00000018560|bA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4)|canalicular multispecific organic anion transporter (ABC superfamily)|multidrug resistance-associated protein 4|multispecif
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Interactome
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Pathway
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Disease
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Publication Reference
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Expression of SLCO1B3 is associated with intratumoral cholestasis and CTNNB1 mutations in hepatocellular carcinoma.
Shigeki Sekine, Reiko Ogawa, Hidenori Ojima andYae Kanai.
Cancer Science 2011 Sep; 102(9):1742.
Application：IHC-P, Human, Liver.
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Expression of SLCO1B3 is associated with intratumoral cholestasis and CTNNB1 mutations in hepatocellular carcinoma.
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