Products

Western Blot (Cell lysate)

Western blot analysis of Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells), Lane 2: NBT-II cell lysate (Rat Wistar bladder tumour cells), Lane 3: PC12 cell lysate (Pheochromocytoma of rat adrenal medulla) with SNW1 polyclonal antibody (Cat # PAB28666) at 1:100-1:500 dilution.

Western Blot

Western blot analysis of Lane 1: RT-4, Lane 2: U-251MG sp, Lane 3: A-431 with SNW1 polyclonal antibody (Cat # PAB28666) at 1:100-1:250 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical staining of human duodenum with SNW1 polyclonal antibody (Cat # PAB28666) shows strong nuclear and cytoplasmic positivity in glandular cells at 1:50-1:200 dilution.

Immunofluorescence

Immunofluorescent staining of human cell line U373 MG with SNW1 polyclonal antibody (Cat # PAB28666) at 1-4 ug/mL shows positivity in nucleus.

Entrez GeneID

22938

Gene Name

SNW1

Gene Alias

Bx42, MGC119379, NCOA-62, PRPF45, Prp45, SKIIP, SKIP

Gene Description

SNW domain containing 1

Omim ID

603055

Gene Ontology

Hyperlink

Gene Summary

This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity. [provided by RefSeq

Other Designations

SKI interacting protein|SKI-interacting protein|homolog of Drosophila BX42|nuclear protein SkiP|nuclear receptor coactivator, 62-kD