PSMA6 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant PSMA6.
Immunogen
Recombinant protein corresponding to amino acids of human PSMA6.
Sequence
EAANWKYKYGYEIPVDMLCKRIADISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHL
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:500-1:1000)
Western Blot (1:100-1:250)
Immunofluorescence (1-4 ug/ml)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of Lane 1: Human cell line RT-4, Lane 2: Human cell line U-251MG sp with PSMA6 polyclonal antibody (Cat # PAB28640) at 1:100-1:250 dilution.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human urinary bladder with PSMA6 polyclonal antibody (Cat # PAB28640) shows strong nuclear and cytoplasmic positivity in urothelial cells at 1:500-1:1000 dilution.Immunofluorescence
Immunofluorescent staining of human cell line U-251MG with PSMA6 polyclonal antibody (Cat # PAB28640) at 1-4 ug/ml shows positivity in nucleus but not nucleoli & cytoplasm. -
Gene Info — PSMA6
Entrez GeneID
5687Protein Accession#
B4DQR4Gene Name
PSMA6
Gene Alias
IOTA, MGC22756, MGC2333, MGC23846, PROS27, p27K
Gene Description
proteasome (prosome, macropain) subunit, alpha type, 6
Omim ID
602855Gene Ontology
HyperlinkGene Summary
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. A pseudogene has been identified on the Y chromosome. [provided by RefSeq
Other Designations
27 kDa prosomal protein|OTTHUMP00000178843|macropain iota chain|macropain subunit iota|multicatalytic endopeptidase complex iota chain|prosomal P27K protein|proteasome alpha 6 subunit|proteasome iota chain|proteasome subunit iota
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Interactome
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Disease
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