LONP1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant LONP1.
Immunogen
Recombinant protein corresponding to human LONP1.
Sequence
VEEKIKQTHRKYLLQEQLKIIKKELGLEKDDKDAIEEKFRERLKELVVPKHVMDVVDEELSKLGLLDNHSSEFNVTRNYLDWLTSIPWGKYSNENLDLARAQAVLEEDHYGMEDVKKRILEFIAVSQLRGSTQGKILCFYGP
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Western Blot (Human: 1:100-1:250, Mouse/Rat: 1:100-1:500
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of lane 1: NIH-3T3, lane 2: NBT-II and lane 3: PC12 cell lysates using LONP1 polyclonal antibody (Cat # PAB28578).Western Blot
Western blot analysis of lane 1: RT-4, lane 2: U-251 MG, lane 3: A-431, lane 4: Liver and lane 5: Tonsil using LONP1 polyclonal antibody (Cat # PAB28578).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) of human duodenum with LONP1 polyclonal antibody (Cat # PAB28578) shows strong cytoplasmic positivity in glandular cells. Retrieval method: HIER pH6 -
Gene Info — LONP1
Entrez GeneID
9361Gene Name
LONP1
Gene Alias
LON, LONP, LonHS, MGC1498, PIM1, PRSS15, hLON
Gene Description
lon peptidase 1, mitochondrial
Omim ID
605490Gene Ontology
HyperlinkGene Summary
This gene encodes a mitochondrial matrix protein in the Lon family of ATP-dependent proteases. A similar E. coli protein regulates gene expression by targeting specific regulatory proteins for degradation. This protein binds a specific sequence in the light and heavy chain promoters of the mitochondrial genome which are involved in regulation of DNA replication and transcription. [provided by RefSeq
Other Designations
LON protease|Lon protease-like protein|hLON ATP-dependent protease|mitochondrial lon peptidase 1|protease, serine, 15
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Interactome
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Publication Reference
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Excessive exercise training causes mitochondrial functional impairment and decreases glucose tolerance in healthy volunteers.
Mikael Flockhart, Lina C Nilsson, Senna Tais, Björn Ekblom, William Apró, Filip J Larsen.
Cell Metabolism 2021 May; 33(5):957.
Application:WB-Ti, Human, Human muscle biopsies.
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Excessive exercise training causes mitochondrial functional impairment and decreases glucose tolerance in healthy volunteers.
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