PARG polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PARG.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human PARG.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Ammonium sulfate precipitation
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry
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Gene Info — PARG
Entrez GeneID
8505Protein Accession#
NP_003622;Q86W56Gene Name
PARG
Gene Alias
PARG99
Gene Description
poly (ADP-ribose) glycohydrolase
Omim ID
603501Gene Ontology
HyperlinkGene Summary
Poly(ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly(ADP-ribose), a reversible covalent-modifier of chromosomal proteins. The protein is found in many tissues and may be subject to proteolysis generating smaller, active products. [provided by RefSeq
Other Designations
poly(ADP-ribose) glycohydrolase 60 kDa isoform
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Interactome
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Disease
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Publication Reference
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Poly(ADP-ribose) polymerase 1 accelerates single-strand break repair in concert with poly(ADP-ribose) glycohydrolase.
Fisher AE, Hochegger H, Takeda S, Caldecott KW.
Molecular and Cellular Biology 2007 Aug; 27(15):5597.
Application:WB-Tr, Human, A-549 cells.
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Two small enzyme isoforms mediate mammalian mitochondrial poly(ADP-ribose) glycohydrolase (PARG) activity.
Meyer RG, Meyer-Ficca ML, Whatcott CJ, Jacobson EL, Jacobson MK.
Experimental Cell Research 2007 Aug; 313(13):2920.
Application:WB-Tr, Human, HeLa cells.
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MNNG-induced cell death is controlled by interactions between PARP-1, poly(ADP-ribose) glycohydrolase, and XRCC1.
Keil C, Grobe T, Oei SL.
The Journal of Biological Chemistry 2006 Nov; 281(45):34394.
Application:WB, Human, Mouse, CHO, HeLa cells.
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Poly(ADP-ribose) polymerase 1 accelerates single-strand break repair in concert with poly(ADP-ribose) glycohydrolase.
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