Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) of human heart tissue with PLA2G5 polyclonal antibody (Cat # PAB28512) followed by peroxidase conjugation of the secondary antibody and DAB staining.
This gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length nature has not been determined. [provided by RefSeq