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Last updated: 2017/2/19

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PPL polyclonal antibody

  • Catalog # : PAB28501
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of PPL
  • Immunogen:
  • A synthetic peptide (conjugated with KLH) corresponding to amino acids 1301-1330 at C-terminal region at human PPL.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Purification:
  • Protein A purification
  • Recommend Usage:
  • Immunohistochemistry (1:10-50)
    Western Blot (1:1000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of PPL polyclonal antibody (Cat # PAB28501) in T47D cell line lysates (35ug/lane). PPL (arrow) was detected using the purified polyclonal antibody.
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) of human skin tissue with PPL polyclonal antibody (Cat # PAB28501) followed by peroxidase conjugation of the secondary antibody and DAB staining.
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 5493
  • Gene Name:
  • PPL
  • Gene Alias:
  • KIAA0568,MGC134872
  • Gene Description:
  • periplakin
  • Gene Summary:
  • The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling. [provided by RefSeq
  • Other Designations:
  • 190 kDa paraneoplastic pemphigus antigen,195 kDa cornified envelope,OTTHUMP00000159922
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