VAV1 polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human tonsil with VAV1 polyclonal antibody (Cat # PAB28500) shows strong cytoplasmic positivity in reaction center cells and lymphoid cells outside reaction centra.
Immunofluorescence
Immunofluorescent staining of human cell line U-251MG with VAV1 polyclonal antibody (Cat # PAB28500) at 1-4 ug/ml shows positivity in cytoplasm & vesicles.
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant VAV1.
Immunogen
Recombinant protein corresponding to amino acids of human VAV1
Sequence
LSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQIDDTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHFLKEMKEAL
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry(1:20-1:50)
Immunofluorescence(1-4 ug/ml)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human tonsil with VAV1 polyclonal antibody (Cat # PAB28500) shows strong cytoplasmic positivity in reaction center cells and lymphoid cells outside reaction centra.Immunofluorescence
Immunofluorescent staining of human cell line U-251MG with VAV1 polyclonal antibody (Cat # PAB28500) at 1-4 ug/ml shows positivity in cytoplasm & vesicles. -
Gene Info — VAV1
Entrez GeneID
7409Protein Accession#
P15498Gene Name
VAV1
Gene Alias
VAV
Gene Description
vav 1 guanine nucleotide exchange factor
Omim ID
164875Gene Ontology
HyperlinkGene Summary
The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. [provided by RefSeq
Other Designations
oncogene vav|vav 1 oncogene|vav proto-oncogene
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Interactome
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Pathway
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