SERPINI1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant SERPINI1.
Immunogen
Recombinant protein corresponding to amino acids of recombinant SERPINI1.
Sequence
DESEVQIPMMYQQGEFYYGEFSDGSNEAGGIYQVLEIPYEGDEISMMLVLSRQEVPLATLEPLVKAQLVEEWANSVKKQKVEVYLPRFTVEQEIDLKDVLKALGI
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry(1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human lateral ventricle wall with sERPINI1 polyclonal antibody (Cat # PAB28451) shows strong cytoplasmic positivity in neuronal cells. -
Gene Info — SERPINI1
Entrez GeneID
5274Protein Accession#
Q99574Gene Name
SERPINI1
Gene Alias
DKFZp781N13156, PI12, neuroserpin
Gene Description
serpin peptidase inhibitor, clade I (neuroserpin), member 1
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq
Other Designations
neuroserpin|serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 1
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Interactome
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Disease
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