Western blot analysis of NAE1 polyclonal antibody (Cat # PAB2845) in mouse brain tissue lysates (35 ug/lane). NAE1 (arrow) was detected using the purified polyclonal antibody.
Western Blot (Transfected lysate)
Western blot analysis of NAE1 (arrow) using rabbit NAE1 polyclonal antibody (Cat # PAB2845). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the NAE1 gene (Lane 2) (Origene Technologies).
Formalin-fixed and paraffin-embedded human breast carcinoma reacted with NAE1 polyclonal antibody (Cat # PAB2845) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
NEDD8-activating enzyme E1 subunit,amyloid beta precursor protein binding protein 1, 59kDa,amyloid beta precursor protein-binding protein 1, 59kD,amyloid protein-binding protein 1,protooncogene protein 1