TAP2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant TAP2.
Immunogen
Recombinant protein corresponding to human TAP2.
Sequence
GSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQA
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:1000-1:2500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4 °C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) of human tonsil with TAP2 polyclonal antibody (Cat # PAB28412) shows strong cytoplasmic positivity in cells in seminiferus ducts. -
Gene Info — TAP2
Entrez GeneID
6891Protein Accession#
Q03519Gene Name
TAP2
Gene Alias
ABC18, ABCB3, APT2, D6S217E, PSF2, RING11
Gene Description
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Gene Ontology
HyperlinkGene Summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces two products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules. [provided by RefSeq
Other Designations
ABC transporter, MHC 2|ATP-binding cassette, sub-family B (MDR/TAP), member 3|OTTHUMP00000029079|OTTHUMP00000038912|OTTHUMP00000038914|antigen peptide transporter 2|peptide supply factor 2|peptide transporter PSF2|transporter 2, ABC (ATP binding cassette)
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Interactome
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Pathway
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Disease
- Abortion
- Adenocarcinoma
- Alzheimer disease
- Arthritis
- Asthma
- Behcet Syndrome
- Bronchiectasis
- Bronchiolitis
- Brucellosis
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