Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) of human cerebral cortex with CKB polyclonal antibody (Cat # PAB28405) shows distinct cytoplasmic positivity in a subset of glial cells.
The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in brain as well as in other tissues, and as a heterodimer with a similar muscle isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. A pseudogene of this gene has been characterized. [provided by RefSeq