MYH7 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant MYH7.
Immunogen
Recombinant protein corresponding to human MYH7.
Sequence
ALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQS
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:500-1:1000)
Immunofluorescence (1-4 ug/ml)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4 °C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) of human heart muscle with MYH7 polyclonal antibody (Cat # PAB28402) shows strong cytoplasmic positivity in myocytes.Immunofluorescence
Immunofluorescence of U251 MG cell line with MYH7 polyclonal antibody (Cat # PAB28402) shows positivity in nucleus but not nucleoli, cytoplasm and focal adhesions. Fixation/Permeabilization: PFA/Triton X-100 -
Gene Info — MYH7
Entrez GeneID
4625Protein Accession#
P12883Gene Name
MYH7
Gene Alias
CMD1S, CMH1, DKFZp451F047, MGC138376, MGC138378, MPD1, MYHCB, SPMD, SPMM
Gene Description
myosin, heavy chain 7, cardiac muscle, beta
Gene Ontology
HyperlinkGene Summary
Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy. [provided by RefSeq
Other Designations
OTTHUMP00000027949|beta-myosin heavy chain|myhc-slow|myopathy, distal 1|myosin heavy chain (AA 1-96)|myosin, heavy polypeptide 7, cardiac muscle, beta|rhabdomyosarcoma antigen MU-RMS-40.7A
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Interactome
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Disease
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