Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) of human testis with DMC1 polyclonal antibody (Cat # PAB28400) shows strong nuclear positivity in subsets of cells in ductus seminiferus.
The protein encoded by this gene is essential for meiotic homologous recombination. Genetic recombination in meiosis plays an important role in generating diversity of genetic information. The product of this gene is structurally and evolutionary related to the products of the yeast RAD51 and E. coli RecA genes. Alternative splice variants of this gene have been described but their full-length nature has not been determined. [provided by RefSeq
DMC1 dosage suppressor of mck1 homolog,DMC1 homologue,disrupted meiotic cDNA1, yeast, homolog of,meiotic recombination protein DMC1/LIM15 homolog