SNAP23 polyclonal antibody
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More Files
- More Functions
Western Blot
Western blot analysis of lane 1: RT-4, lane 2: U-251 MG, lane 3: A-431, lane 4: Liver and lane 5: Tonsil using SNAP23 polyclonal antibody (Cat # PAB28395).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) of human tonsil with SNAP23 polyclonal antibody (Cat # PAB28395) shows strong cytoplasmic positivity in reaction center cells and lymphoid cells outside reaction center.
Immunofluorescence
Immunofluorescence of U-2 OS cell line with SNAP23 polyclonal antibody (Cat # PAB28395) shows positivity in plasma membrane. Fixation/Permeabilization: PFA/Triton X-100
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant SNAP23.
Immunogen
Recombinant protein corresponding to human SNAP23.
Sequence
QINKDMRETEKTLTELNKCCGLCVCPCNRTKNFESGKAYKTTWGDGGENSPCNVVSKQPGPVTNGQLQQPTTGAASGGYIKRITNDAREDEMEENLTQVGSILGNLKDMALNIGNEIDAQNPQIKRITDKADTNRDRIDIANA
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:1000-1:2500)
Immunofluorescence (1-4 ug/ml)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4 °C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of lane 1: RT-4, lane 2: U-251 MG, lane 3: A-431, lane 4: Liver and lane 5: Tonsil using SNAP23 polyclonal antibody (Cat # PAB28395).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) of human tonsil with SNAP23 polyclonal antibody (Cat # PAB28395) shows strong cytoplasmic positivity in reaction center cells and lymphoid cells outside reaction center.Immunofluorescence
Immunofluorescence of U-2 OS cell line with SNAP23 polyclonal antibody (Cat # PAB28395) shows positivity in plasma membrane. Fixation/Permeabilization: PFA/Triton X-100 -
Gene Info — SNAP23
Entrez GeneID
8773Protein Accession#
O00161Gene Name
SNAP23
Gene Alias
HsT17016, SNAP23A, SNAP23B
Gene Description
synaptosomal-associated protein, 23kDa
Omim ID
602534Gene Ontology
HyperlinkGene Summary
Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000161263|synaptosomal-associated protein 23
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Interactome
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Pathway
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Disease
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