ADRB2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ADRB2.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to residues surrounding S261 of human ADRB2.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein A purification
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocarcinomareacted with ADRB2 polyclonal antibody (Cat # PAB2838), which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. -
Gene Info — ADRB2
Entrez GeneID
154Protein Accession#
P07550;NP_000015Gene Name
ADRB2
Gene Alias
ADRB2R, ADRBR, B2AR, BAR, BETA2AR
Gene Description
adrenergic, beta-2-, receptor, surface
Gene Ontology
HyperlinkGene Summary
This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq
Other Designations
beta-2 adrenergic receptor|beta-2 adrenoceptor|catecholamine receptor
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Interactome
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Pathway
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Disease
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Publication Reference
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Sodium/calcium exchanger is upregulated by sulfide signaling, forms complex with the β1 and β3 but not β2 adrenergic receptors, and induces apoptosis.
Markova J, Hudecova S, Soltysova A, Sirova M, Csaderova L, Lencesova L, Ondrias K, Krizanova O.
Pflügers Archiv 2014 Jul; 466(7):1329.
Application:WB-Ce, Human, HeLa cells.
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Association between a beta2-adrenergic receptor polymorphism and elite endurance performance.
Wolfarth B, Rankinen T, Muhlbauer S, Scherr J, Boulay MR, Perusse L, Rauramaa R, Bouchard C.
Metabolism 2007 Dec; 56(12):1649.
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High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor.
Cherezov V, Rosenbaum DM, Hanson MA, Rasmussen SG, Thian FS, Kobilka TS, Choi HJ, Kuhn P, Weis WI, Kobilka BK, Stevens RC.
Science 2007 Nov; 318(5854):1258.
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Sodium/calcium exchanger is upregulated by sulfide signaling, forms complex with the β1 and β3 but not β2 adrenergic receptors, and induces apoptosis.
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