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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical staining of human stomach with TAPBP polyclonal antibody (Cat # PAB28223) shows strong cytoplasmic and membranous positivity in glandular cells at 1:20-1:50 dilution.

Entrez GeneID

6892

Gene Name

TAPBP

Gene Alias

NGS17, TAPA, TPN, TPSN, tapasin

Gene Description

TAP binding protein (tapasin)

Omim ID

601962 604571

Gene Ontology

Hyperlink

Gene Summary

This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq

Other Designations

TAP-associated protein|TAP-binding protein|tapasin