ACVR2A polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human rectum with ACVR2A polyclonal antibody (Cat # PAB28207) shows strong cytoplasmic and membranous positivity in glandular cells at 1:50-1:200 dilution.
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant ACVR2A.
Immunogen
Recombinant protein corresponding to amino acids of recombinant ACVR2A.
Sequence
CEGNMCNEKFSYFPEMEVTQPTSNPVTPKPPYYN
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human rectum with ACVR2A polyclonal antibody (Cat # PAB28207) shows strong cytoplasmic and membranous positivity in glandular cells at 1:50-1:200 dilution. -
Gene Info — ACVR2A
Entrez GeneID
92Protein Accession#
P27037Gene Name
ACVR2A
Gene Alias
ACTRII, ACVR2
Gene Description
activin A receptor, type IIA
Omim ID
102581Gene Ontology
HyperlinkGene Summary
This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. [provided by RefSeq
Other Designations
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Interactome
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Pathway
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Disease
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