CDKL5 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CDKL5.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human CDKL5.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
The CDKL5 polyclonal antibody (Cat # PAB2814) is used in Western blot to detect STK9 in mouse lung tissue lysate.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with CDKL5 polyclonal antibody (Cat # PAB2814) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. -
Gene Info — CDKL5
Entrez GeneID
6792Protein Accession#
NP_003150;O76039Gene Name
CDKL5
Gene Alias
ISSX, STK9
Gene Description
cyclin-dependent kinase-like 5
Gene Ontology
HyperlinkGene Summary
This gene is a member of Ser/Thr protein kinase family and encodes a phosphorylated protein with protein kinase activity. Mutations in this gene have been associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT). Alternate transcriptional splice variants have been characterized. [provided by RefSeq
Other Designations
OTTHUMP00000023002|OTTHUMP00000023003|serine/threonine kinase 9
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Interactome
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Disease
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Publication Reference
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Disruption of the serine/threonine kinase 9 gene causes severe X-linked infantile spasms and mental retardation.
Kalscheuer VM, Tao J, Donnelly A, Hollway G, Schwinger E, Kubart S, Menzel C, Hoeltzenbein M, Tommerup N, Eyre H, Harbord M, Haan E, Sutherland GR, Ropers HH, Gecz J.
American Journal of Human Genetics 2003 Jun; 72(6):1401.
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Identification and characterization of a novel serine-threonine kinase gene from the Xp22 region.
Montini E, Andolfi G, Caruso A, Buchner G, Walpole SM, Mariani M, Consalez G, Trump D, Ballabio A, Franco B.
Genomics 1998 Aug; 51(3):427.
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Disruption of the serine/threonine kinase 9 gene causes severe X-linked infantile spasms and mental retardation.
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