TP53 (phospho S15) polyclonal antibody (Biotin)
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Specification
Product Description
Chicken polyclonal antibody against synthetic phosphopeptide of TP53
Immunogen
Synthetic phosphopeptide corresponding to amino acids of TP53
Sequence
MEEPQSDPSVEPPL(pS)QETFSDLWK
Host
Chicken
Reactivity
Human
Form
Liquid
Conjugation
Biotin
Purification
Antigen affinity purification
Concentration
0.2 mg/mL
Isotype
IgY
Storage Buffer
In Phosphate-Buffered Saline with 0.02% Sodium Azide.
Storage Instruction
Store at 4°C. For long term storage, aliquot and store at -20°C. Avoid repeated freezing and thawing cycles.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immuno-MRM (multiple reaction monitoring)
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Gene Info — TP53
Entrez GeneID
7157Gene Name
TP53
Gene Alias
FLJ92943, LFS1, TRP53, p53
Gene Description
tumor protein p53
Gene Ontology
HyperlinkGene Summary
This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity. [provided by RefSeq
Other Designations
p53 antigen|p53 transformation suppressor|p53 tumor suppressor|phosphoprotein p53|transformation-related protein 53
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Interactome
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Pathway
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Disease
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