SMG6 polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human cerebellum with SMG6 polyclonal antibody (Cat # PAB27944) shows distinct cytoplasmic and nucleolar/ nuclear positivity in Purkinje cells.
Immunofluorescence
Immunofluorescent staining of human cell line U-2 OS with SMG6 polyclonal antibody (Cat # PAB27944) at 1-4 ug/mL dilution shows positivity in nucleus, nucleoli and cytoplasm.
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant SMG6.
Immunogen
Recombinant protein corresponding to amino acids of human SMG6.
Sequence
MAEGLERVRISASELRGILATLAPQAGSRENMKELKEARPRKDNRRPDLEIYKPGLSRLRNKPKIKEPPGSEEFKDEIVNDRDCSAVENGTQPVKDVCKELNNQEQNGPIDP
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:500-1:1000)
Immunofluorescence (1-4 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2, (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human cerebellum with SMG6 polyclonal antibody (Cat # PAB27944) shows distinct cytoplasmic and nucleolar/ nuclear positivity in Purkinje cells.Immunofluorescence
Immunofluorescent staining of human cell line U-2 OS with SMG6 polyclonal antibody (Cat # PAB27944) at 1-4 ug/mL dilution shows positivity in nucleus, nucleoli and cytoplasm. -
Gene Info — SMG6
Entrez GeneID
23293Gene Name
SMG6
Gene Alias
C17orf31, EST1A, KIAA0732, SMG-6
Gene Description
Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans)
Omim ID
610963Gene Ontology
HyperlinkGene Summary
SMG6 is involved in nonsense-mediated mRNA decay (Fukuhara et al., 2005 [PubMed 15721257]).[supplied by OMIM
Other Designations
EST1 telomerase component homolog A|Est1p-like|Smg-6 homolog, nonsense mediated mRNA decay factor|ever shorter telomeres 1A
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Interactome
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Disease
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