P2RX7 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of P2RX7.
Immunogen
A synthetic peptide corresponding to 16 amino acid at internal region of human P2RX7.
Host
Rabbit
Reactivity
Human, Monkey
Specificity
BLAST analysis of the peptide immunogen showed no homology with other human proteins, except DDX59 (56%).
Form
Liquid
Purification
Immunoaffinity chromatography
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (10-20 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) of human pancreas, nerve with P2RX7 polyclonal antibody (Cat # PAB27822). Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. -
Gene Info — P2RX7
Entrez GeneID
5027Protein Accession#
Q99572Gene Name
P2RX7
Gene Alias
MGC20089, P2X7
Gene Description
purinergic receptor P2X, ligand-gated ion channel, 7
Gene Ontology
HyperlinkGene Summary
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants which would encode different isoforms have been identified although some fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq
Other Designations
ATP receptor|P2X purinoceptor 7|P2X7 receptor|P2Z receptor|purinergic receptor P2X7
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