Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) of human heart tissue with SCN5A polyclonal antibody (Cat # PAB27814). Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq
cardiac sodium channel alpha subunit,sodium channel, voltage-gated, type V, alpha (long QT syndrome 3),voltage-gated sodium channel type V alpha