DAPK2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of DAPK2.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human DAPK2.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
The DAPK2 polyclonal antibody (Cat # PAB2780) is used in Western blot to detect DAPK2 in mouse lung tissue lysate.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with DAPK2 polyclonal antibody (Cat # PAB2780) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma. -
Gene Info — DAPK2
Entrez GeneID
23604Protein Accession#
Q9UIK4Gene Name
DAPK2
Gene Alias
DRP-1, MGC119312
Gene Description
death-associated protein kinase 2
Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites. [provided by RefSeq
Other Designations
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Interactome
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Pathway
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Publication Reference
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DNA methylation and histone deacetylation associated with silencing DAP kinase gene expression in colorectal and gastric cancers.
Satoh A, Toyota M, Itoh F, Kikuchi T, Obata T, Sasaki Y, Suzuki H, Yawata A, Kusano M, Fujita M, Hosokawa M, Yanagihara K, Tokino T, Imai K.
British Journal of Cancer 2002 Jun; 86(11):1817.
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High frequency of promoter hypermethylation of the death-associated protein-kinase gene in nasopharyngeal carcinoma and its detection in the peripheral blood of patients.
Wong TS, Chang HW, Tang KC, Wei WI, Kwong DL, Sham JS, Yuen AP, Kwong YL.
Clinical Cancer Research 2002 Feb; 8(2):433.
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Hypermethylation of multiple genes in tumor tissues and voided urine in urinary bladder cancer patients.
Chan MW, Chan LW, Tang NL, Tong JH, Lo KW, Lee TL, Cheung HY, Wong WS, Chan PS, Lai FM, To KF.
Clinical Cancer Research 2002 Feb; 8(2):464.
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DNA methylation and histone deacetylation associated with silencing DAP kinase gene expression in colorectal and gastric cancers.
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