Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) of human brain, neurons and glia with NR4A3 polyclonal antibody (Cat # PAB27791). Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcriptional activator. The protein can efficiently bind the NGFI-B Response Element (NBRE). Three different versions of extraskeletal myxoid chondrosarcomas (EMCs) are the result of reciprocal translocations between this gene and other genes. The translocation breakpoints are associated with Nuclear Receptor Subfamily 4, Group A, Member 3 (on chromosome 9) and either Ewing Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II, TATA Box-Binding Protein-Associated Factor, 68-KD (on chromosome 17), or Transcription factor 12 (on chromosome 15). Four transcript variants encoding three distinct isoforms have been identified for this gene. [provided by RefSeq
OTTHUMP00000022775,OTTHUMP00000022776,chondrosarcoma, extraskeletal myxoid, fused to EWS,mitogen induced nuclear orphan receptor,neuron derived orphan receptor,translocated in extraskeletal chondrosarcoma