MAPKAPK5 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of MAPKAPK5.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to residues surrounding T182 of human MAPKAPK5.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of MAPKAPK5 polyclonal antibody (Cat # PAB2779) in HeLa cell line lysates (35 ug/lane). MAPKAPK5 (arrow) was detected using the purified polyclonal antibody. -
Gene Info — MAPKAPK5
Entrez GeneID
8550Protein Accession#
NP_003659;Q8IW41Gene Name
MAPKAPK5
Gene Alias
PRAK
Gene Description
mitogen-activated protein kinase-activated protein kinase 5
Omim ID
606723Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq
Other Designations
p38-regulated/activated protein kinase
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Interactome
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Pathway
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Publication Reference
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p62 functions as a p38 MAP kinase regulator.
Sudo T, Maruyama M, Osada H.
Biochemical and Biophysical Research Communications 2000 Mar; 269(2):521.
Application:IF, IP, WB-Ce, Human, HeLa cells.
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PRAK, a novel protein kinase regulated by the p38 MAP kinase.
New L, Jiang Y, Zhao M, Liu K, Zhu W, Flood LJ, Kato Y, Parry GC, Han J.
The EMBO Journal 1998 Jun; 17(12):3372.
Application:IP-WB, Human, HEK 293, A549, HeLa, HepG2, Jurkat cells.
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MAPKAPK5, a novel mitogen-activated protein kinase (MAPK)-activated protein kinase, is a substrate of the extracellular-regulated kinase (ERK) and p38 kinase.
Ni H, Wang XS, Diener K, Yao Z.
Biochemical and Biophysical Research Communications 1998 Feb; 243(2):492.
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p62 functions as a p38 MAP kinase regulator.
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