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Last updated: 2016/10/23
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MAP3K12 polyclonal antibody

  • Catalog # : PAB2777
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of MAP3K12.
  • Immunogen:
  • A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human MAP3K12.
  • Host:
  • Rabbit
  • Reactivity:
  • Human, Mouse
  • Form:
  • Liquid
  • Purification:
  • Protein G purification
  • Recommend Usage:
  • Western Blot (1:1000)
    Immunohistochemistry (1:50-100)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot
  • Western Blot
  • Western blot analysis of MAP3K12 polyclonal antibody (Cat # PAB2777) in HL-60 cell lysate (lane A) and in mouse kidney tissue lysate (lane B) . MAP3K12 (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Formalin-fixed and paraffin-embedded human cancer tissue reacted with MAP3K12 polyclonal antibody (Cat # PAB2777) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.
  • Application Image
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
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  • Gene Information
  • Entrez GeneID:
  • 7786
  • Protein Accession#:
  • NP_006292;Q12852
  • Gene Name:
  • MAP3K12
  • Gene Alias:
  • Gene Description:
  • mitogen-activated protein kinase kinase kinase 12
  • Gene Summary:
  • The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a leucine-zipper domain, and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. [provided by RefSeq
  • Other Designations:
  • dual leucine zipper kinase DLK,leucine zipper protein kinase,protein kinase MUK,zipper protein kinase
  • Gene Pathway
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